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1

Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism

Dina Petranovic, Keith Tyo, Goutham N. Vemuri, Jens Nielsen

Journal:

FEMS Yeast Research

Année:

2010

Langue:

english

Fichier:

PDF, 651 KB

english, 2010

2

Stabilized gene duplication enables long-term selection-free heterologous pathway expression

Tyo, Keith E J, Ajikumar, Parayil Kumaran, Stephanopoulos, Gregory

Journal:

Nature Biotechnology

Année:

2009

Langue:

english

Fichier:

PDF, 473 KB

english, 2009

3

Virus-like particles: the future of microbial factories and cell-free systems as platforms for vaccine development

Rodríguez-Limas, William A, Sekar, Karthik, Tyo, Keith EJ

Journal:

Current Opinion in Biotechnology

Année:

2013

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2013

4

Characterizing and predicting carboxylic acid reductase activity for diversifying bioaldehyde production

Moura, Matthew, Pertusi, Dante, Lenzini, Stephen, Bhan, Namita, Broadbelt, Linda J., Tyo, Keith E.J.

Journal:

Biotechnology and Bioengineering

Année:

2016

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2016

5

CellSort: A support vector machine tool for optimizing fluorescence-activated cell sorting and reducing experimental effort

Yu, Jessica S., Pertusi, Dante A., Adeniran, Adebola V., Tyo, Keith E. J.

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 288 KB

english, 2016

6

High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing

de Paz, Alexandra M, Cybulski, Thaddeus R, Marblestone, Adam H, Zamft, Bradley M, Church, George M, Boyden, Edward S, Kording, Konrad P, Tyo, Keith E J

Journal:

Nucleic Acids Research

Année:

2018

Langue:

english

Fichier:

PDF, 1008 KB

english, 2018

7

A high-throughput screen for hyaluronic acid accumulation in recombinant Escherichia coli transformed by libraries of engineered sigma factors

Huimin Yu, Keith Tyo, Hal Alper, Daniel Klein-Marcuschamer, Gregory Stephanopoulos

Journal:

Biotechnology and Bioengineering

Année:

2008

Langue:

english

Fichier:

PDF, 581 KB

english, 2008

8

Identification of gene disruptions for increased poly-3-hydroxybutyrate accumulation in Synechocystis PCC 6803

Keith E. J. Tyo, Yong-Su Jin, Freddy A. Espinoza, Gregory Stephanopoulos

Journal:

Biotechnology Progress

Année:

2009

Langue:

english

Fichier:

PDF, 583 KB

english, 2009

9

Analysis of polyhydroxybutyrate flux limitations by systematic genetic and metabolic perturbations

Keith E.J. Tyo, Curt R. Fischer, Fritz Simeon, Gregory Stephanopoulos

Journal:

Metabolic Engineering

Année:

2010

Langue:

english

Fichier:

PDF, 681 KB

english, 2010

10

Molecular and process design for rotavirus-like particle production inSaccharomyces cerevisiae

William A Rodríguez-Limas, Keith EJ Tyo, Jens Nielsen, Octavio T Ramírez, Laura A Palomares

Journal:

Microbial Cell Factories

Année:

2011

Langue:

english

Fichier:

PDF, 2.19 MB

english, 2011

11

Meeting report: Gothenburg Life Science Conference XI – Industrial Systems Biology

Keith E.J. Tyo, Verena Siewers

Journal:

Biotechnology Journal

Année:

2011

Langue:

english

Fichier:

PDF, 599 KB

english, 2011

12

Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae

Zihe Liu, Keith E.J. Tyo, José L. Martínez, Dina Petranovic, Jens Nielsen

Journal:

Biotechnology and Bioengineering

Année:

2012

Langue:

english

Fichier:

PDF, 848 KB

english, 2012

13

Expanding the metabolic engineering toolbox: more options to engineer cells

Keith E. Tyo, Hal S. Alper, Gregory N. Stephanopoulos

Journal:

Trends in Biotechnology

Année:

2007

Langue:

english

Fichier:

PDF, 362 KB

english, 2007

14

Synthetic biology: Emerging methodologies to catalyze the metabolic engineering design cycle

Christina D. Smolke, Keith E.J. Tyo

Journal:

Metabolic Engineering

Année:

2012

Langue:

english

Fichier:

PDF, 94 KB

english, 2012

15

Engineering of vesicle trafficking improves heterologous protein secretion in Saccharomyces cerevisiae

Jin Hou, Keith Tyo, Zihe Liu, Dina Petranovic, Jens Nielsen

Journal:

Metabolic Engineering

Année:

2012

Langue:

english

Fichier:

PDF, 586 KB

english, 2012

16

Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae

Jin Hou, Keith E.J. Tyo, Zihe Liu, Dina Petranovic, Jens Nielsen

Journal:

FEMS Yeast Research

Année:

2012

Langue:

english

Fichier:

PDF, 419 KB

english, 2012

17

Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress

Keith EJ Tyo, Zihe Liu, Dina Petranovic, Jens Nielsen

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 658 KB

english, 2012

18

Toward design-based engineering of industrial microbes

Keith EJ Tyo, Kanokarn Kocharin, Jens Nielsen

Journal:

Current Opinion in Microbiology

Année:

2010

Langue:

english

Fichier:

PDF, 473 KB

english, 2010

19

Terpenoids: Opportunities for Biosynthesis of Natural Product Drugs Using Engineered Microorganisms

Ajikumar, Parayil Kumaran, Tyo, Keith, Carlsen, Simon, Mucha, Oliver, Phon, Too Heng, Stephanopoulos, Gregory

Journal:

Molecular Pharmaceutics

Année:

2008

Langue:

english

Fichier:

PDF, 347 KB

english, 2008

20

Impact of protein uptake and degradation on recombinant protein secretion in yeast

Tyo, Keith E. J., Liu, Zihe, Magnusson, Ylva, Petranovic, Dina, Nielsen, Jens

Journal:

Applied Microbiology and Biotechnology

Année:

2014

Langue:

english

Fichier:

PDF, 1.61 MB

english, 2014

21

Blocking endocytotic mechanisms to improve heterologous protein titers in Saccharomyces cerevisiae

Rodríguez-Limas, William A., Tannenbaum, Victoria, Tyo, Keith E. J.

Journal:

Biotechnology and Bioengineering

Année:

2015

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2015

22

Yeast-based biosensors: design and applications

Adeniran, Adebola, Sherer, Michael, Tyo, Keith E.J.

Journal:

FEMS Yeast Research

Année:

2014

Langue:

english

Fichier:

PDF, 624 KB

english, 2014

23

Editorial overview: Cell and pathway engineering. Moving from possible to profitable: recent innovations in cell and pathway engineering

Lütke-Eversloh, Tina, Tyo, Keith EJ

Journal:

Current Opinion in Biotechnology

Année:

2014

Langue:

english

Fichier:

PDF, 241 KB

english, 2014

24

Regulatory effects on central carbon metabolism from poly-3-hydroxybutryate synthesis

Sekar, Karthik, Tyo, Keith E.J.

Journal:

Metabolic Engineering

Année:

2015

Langue:

english

Fichier:

PDF, 1.59 MB

english, 2015

25

Statistical Analysis of Molecular Signal Recording

Glaser, Joshua I., Zamft, Bradley M., Marblestone, Adam H., Moffitt, Jeffrey R., Tyo, Keith, Boyden, Edward S., Church, George, Kording, Konrad P., Markel, Scott

Journal:

PLoS Computational Biology

Année:

2013

Langue:

english

Fichier:

PDF, 766 KB

english, 2013

26

[Methods in Enzymology] Synthetic Biology, Part A Volume 497 || Directed Evolution of Promoters and Tandem Gene Arrays for Customizing RNA Synthesis Rates and Regulation

Tyo, Keith E.J.

Année:

2011

Langue:

english

Fichier:

PDF, 463 KB

english, 2011

27

Evaluating Enzymatic Synthesis of Small Molecule Drugs

Moura, Matthew, Finkle, Justin, Stainbrook, Sarah, Greene, Jennifer, Broadbelt, Linda J., Tyo, Keith E.J.

Journal:

Metabolic Engineering

Année:

2015

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2015

28

Exploring De Novo metabolic pathways from pyruvate to propionic acid

Stine, Andrew, Zhang, Miaomin, Ro, Soo, Clendennen, Stephanie, Shelton, Michael C., Tyo, Keith E.J., Broadbelt, Linda J.

Journal:

Biotechnology Progress

Année:

2016

Langue:

english

Fichier:

PDF, 472 KB

english, 2016

29

Plasmid-based one-pot saturation mutagenesis

Wrenbeck, Emily E, Klesmith, Justin R, Stapleton, James A, Adeniran, Adebola, Tyo, Keith E J, Whitehead, Timothy A

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 360 KB

english, 2016

30

A Glucose-Sensing Toggle Switch for Autonomous, High Productivity Genetic Control

Bothfeld, William, Kapov, Grace, Tyo, Keith E. J.

Journal:

ACS Synthetic Biology

Année:

2017

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2017

31

Modulating and evaluating receptor promiscuity through directed evolution and modeling

Stainbrook, Sarah C., Yu, Jessica S., Reddick, Michael P., Bagheri, Neda, Tyo, Keith E. J.

Journal:

Protein Engineering Design and Selection

Année:

2017

Langue:

english

Fichier:

PDF, 1.05 MB

english, 2017

32

Generation and Validation of the iKp1289 Metabolic Model for Klebsiella pneumoniae KPPR1

Henry, Christopher S., Rotman, Ella, Lathem, Wyndham W., Tyo, Keith E. J., Hauser, Alan R., Mandel, Mark J.

Journal:

The Journal of Infectious Diseases

Année:

2017

Langue:

english

Fichier:

PDF, 918 KB

english, 2017

33

Increased processivity, misincorporation, and nucleotide incorporation efficiency in Sulfolobus solfataricus Dpo4 thumb domain mutations

Wang, Li, Liang, Chenchen, Wu, Jing, Liu, Liming, Tyo, Keith E.J.

Journal:

Applied and Environmental Microbiology

Année:

2017

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2017

34

DNA binding strength increases the processivity and activity of a Y-Family DNA polymerase

Wu, Jing, de Paz, Alexandra, Zamft, Bradley M., Marblestone, Adam H., Boyden, Edward S., Kording, Konrad P., Tyo, Keith E. J.

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2017

35

Acceleration Strategies to Enhance Metabolic Ensemble Modeling Performance

Greene, Jennifer L., Wäechter, Andreas, Tyo, Keith E.J., Broadbelt, Linda J.

Journal:

Biophysical Journal

Année:

2017

Langue:

english

Fichier:

PDF, 1.80 MB

english, 2017

36

Predicting novel substrates for enzymes with minimal experimental effort with active learning

Pertusi, Dante A., Moura, Matthew E., Jeffryes, James G., Prabhu, Siddhant, Walters Biggs, Bradley, Tyo, Keith E.J.

Journal:

Metabolic Engineering

Année:

2017

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2017

37

Detection of a peptide biomarker by engineered yeast receptors

Adeniran, Adebola, Stainbrook, Sarah, Bostick, John, Tyo, Keith

Journal:

ACS Synthetic Biology

Année:

2018

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2018

38

Development of novel metabolite-responsive transcription factors via transposon-mediated protein fusion

Younger, Andrew K D, Su, Peter Y, Shepard, Andrea J, Udani, Shreya V, Cybulski, Thaddeus R, Tyo, Keith E J, Leonard, Joshua N

Journal:

Protein Engineering Design and Selection

Année:

2018

Langue:

english

Fichier:

PDF, 810 KB

english, 2018

39

N-Terminal-Based Targeted, Inducible Protein Degradation in Escherichia coli

Sekar, Karthik, Gentile, Andrew M., Bostick, John W., Tyo, Keith E. J., Herman, Christophe

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.85 MB

english, 2016

40

Correction to “Detection of a Peptide Biomarker by Engineered Yeast Receptors”

Adeniran, Adebola, Stainbrook, Sarah, Bostick, John W., Tyo, Keith E. J.

Journal:

ACS Synthetic Biology

Année:

2018

Langue:

english

Fichier:

PDF, 267 KB

english, 2018

41

Draft Genome Sequence of a Multidrug-Resistant Klebsiella quasipneumoniae subsp. similipneumoniae Isolate from a Clinical Source

Ozer, Egon A., Morris, Andrew R., Krapp, Fiorella, Henry, Christopher S., Tyo, Keith E., Lathem, Wyndham W., Hauser, Alan R.

Journal:

Genome Announcements

Année:

2016

Langue:

english

Fichier:

PDF, 171 KB

english, 2016

42

Metabolic kinetic modeling provides insight into complex biological questions, but hurdles remain

Strutz, Jonathan, Martin, Jacob, Greene, Jennifer, Broadbelt, Linda, Tyo, Keith

Journal:

Current Opinion in Biotechnology

Année:

2019

Fichier:

PDF, 361 KB

2019

43

Metabolic kinetic modeling provides insight into complex biological questions, but hurdles remain

Strutz, Jonathan, Martin, Jacob, Greene, Jennifer, Broadbelt, Linda, Tyo, Keith

Journal:

Current Opinion in Biotechnology

Année:

2019

Langue:

english

Fichier:

PDF, 361 KB

english, 2019

44

Model-guided mechanism discovery and parameter selection for directed evolution

Stainbrook, Sarah C., Tyo, Keith E. J.

Journal:

Applied Microbiology and Biotechnology

Année:

2019

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2019